mitoguazone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antineoplastics, nucleotoxic agents 3362 459-86-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mitoguazone
  • Methylglyoxal bis(amidinohydrazone)
  • Methylglyoxal bis(guanylhydrazone)
Antineoplastic agent effective against myelogenous leukemia in experimental animals. Also acts as an inhibitor of animal S-adenosylmethionine decarboxylase.
  • Molecular weight: 184.21
  • Formula: C5H12N8
  • CLOGP: -2.58
  • LIPINSKI: 1
  • HAC: 8
  • HDO: 6
  • TPSA: 148.52
  • ALOGS: -2.77
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01XX16 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
OTHER ANTINEOPLASTIC AGENTS
Other antineoplastic agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:68495 Type I cell-death inducers
CHEBI has role CHEBI:78024 S-adenosylmethionine decarboxylase inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.72 Basic
pKa2 8.02 Basic
pKa3 2.45 Basic
pKa4 1.45 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
S-adenosylmethionine decarboxylase proenzyme Enzyme IC50 6 CHEMBL
Amiloride-sensitive amine oxidase [copper-containing] Enzyme IC50 5.82 CHEMBL

External reference:

IDSource
D07258 KEGG_DRUG
C0026251 UMLSCUI
CHEBI:43996 CHEBI
MGB PDB_CHEM_ID
CHEMBL216913 ChEMBL_ID
DB12967 DRUGBANK_ID
D008935 MESH_DESCRIPTOR_UI
5351154 PUBCHEM_CID
2453 INN_ID
OD5Q0L447W UNII
006109 NDDF

Pharmaceutical products:

None